Protein level in Df(h22q11)/+ mice and wild-type littermates
| Type | Marker | Function | PFC | DStr | Hipp |
|---|---|---|---|---|---|
| Synaptic | PSD-95 | Scaffolding protein at excitatory post synaptic densities | x | x | x |
| Synaptophysin | Synaptic vesicle protein | x | x | x | |
| Synapsin 1 | Phosphoprotein associated with surface of synaptic vesicles | x | x | x | |
| Drebrin | Actin-binding protein involved in neuronal /spine growth | x | x | x | |
| Gephyrin | Scaffolding protein in inhibitory synaptic densities | x | x | x | |
| Cell type | NeuN | Nuclear antigen. Biomarker of neurons | (↓) | x | x |
| GFAP | Intermediate filament in astrocytes | x | x | x | |
| Glutamate | GluR1 | AMPA receptor subunit | x | ↑ | x |
| GluR2 | AMPA receptor subunit | x | x | x | |
| NR2A | NMDA receptor subunit | x | x | x | |
| NR2B | NMDA receptor subunit | x | x | x | |
| VGluT1 | Vesicular glutamate transporter at vesicle membrane | x | x | x | |
| GABA | GABAA α1 | GABAA receptor subunit | x | x | x |
| KCC2 | Neuron specific potassium-chloride transporter | x | x | x | |
| VGAT | Vesicular GABA transporter found on synaptic vesicle membrane | x | x | x | |
| GAD 65/6 | Enzymes catalyzing decarboxylation of glutamate to GABA | x | x | x |
DStr = dorsal striatum; GABA = γ-aminobutyric acid; Hipp = hippocampus; NMDA = N-methyl-d-aspartate; PFC = prefrontal cortex; ↓ = decreased; ↑ = increased; x = no effect; () = did not replicate.