Table 2

Protein level in Df(h22q11)/+ mice and wild-type littermates

SynapticPSD-95Scaffolding protein at excitatory post synaptic densitiesxxx
SynaptophysinSynaptic vesicle proteinxxx
Synapsin 1Phosphoprotein associated with surface of synaptic vesiclesxxx
DrebrinActin-binding protein involved in neuronal /spine growthxxx
GephyrinScaffolding protein in inhibitory synaptic densitiesxxx
Cell typeNeuNNuclear antigen. Biomarker of neurons(↓)xx
GFAPIntermediate filament in astrocytesxxx
GlutamateGluR1AMPA receptor subunitxx
GluR2AMPA receptor subunitxxx
NR2ANMDA receptor subunitxxx
NR2BNMDA receptor subunitxxx
VGluT1Vesicular glutamate transporter at vesicle membranexxx
GABAGABAA α1GABAA receptor subunitxxx
KCC2Neuron specific potassium-chloride transporterxxx
VGATVesicular GABA transporter found on synaptic vesicle membranexxx
GAD 65/6Enzymes catalyzing decarboxylation of glutamate to GABAxxx
  • DStr = dorsal striatum; GABA = γ-aminobutyric acid; Hipp = hippocampus; NMDA = N-methyl-d-aspartate; PFC = prefrontal cortex; ↓ = decreased; ↑ = increased; x = no effect; () = did not replicate.