Table 2

Late positive potential amplitudes and task-related liking and wanting ratings for cocaine for each condition in healthy controls at baseline and in individuals with cocaine use disorders at baseline and 6-month follow-up

Group, time point; mean ± SD
MeasureControl, baselineCUD, baselineCUD, follow-up
Pleasant LPP, μV*1.12 ± 1.79−0.28 ± 2.000.19 ± 1.54
Drug LPP, μV*−0.41 ± 1.030.27 ± 1.90−0.12 ± 1.44
Neutral LPP, μV−1.63 ± 1.80−0.51 ± 1.75−0.89 ± 1.44
Drug – pleasant LPP, μV*−1.54 ± 1.500.56 ± 1.29−0.31 ± 1.61
Pleasant ratings
 Liking*1.45 ± 0.962.92 ± 1.712.82 ± 1.76
 Wanting2.55 ± 3.402.28 ± 1.472.77 ± 1.69
Drug ratings
 Liking*1.33 ± 0.963.38 ± 1.753.55 ± 2.32
 Wanting2.56 ± 3.333.56 ± 1.693.59 ± 2.38
Neutral ratings
 Liking1.60 ± 1.112.34 ± 1.732.45 ± 1.59
 Wanting1.67 ± 2.081.98 ± 1.412.39 ± 1.57
Drug – pleasant ratings
 Liking−0.17 ± 0.330.45 ± 1.910.73 ± 1.37
 Wanting*−0.06 ± 0.161.27 ± 1.550.82 ± 1.48
  • CUD = cocaine use disorder; LPP = late positive potential; SD = standard deviation.

  • * Significant difference between controls and CUD at baseline (p < 0.05).

  • Significant difference between controls at baseline and CUD at follow-up (p < 0.05).

  • Significant difference in CUD between baseline and follow-up (p < 0.05).