Additive genetic, common and specific environmental estimates (with 95% CI) of full ACE genetic model*
| Estimate (95% CI)† | |||
|---|---|---|---|
| Region | h2 | χ2 | e2 |
| Whole brain | 0.50 (0.14–0.92) | 0.40 (0.00–0.75) | 0.10 (0.08–0.15) |
| Grey matter | 0.39 (0.06–0.90) | 0.48 (0.00–0.80) | 0.13 (0.09–0.20) |
| White matter | 0.73 (0.23–0.90) | 0.12 (0.00–0.62) | 0.15 (0.10–0.23) |
| Right hippocampus | 0.28 (0.00–0.12) | 0.38 (0.00–0.99) | 0.34 (0.26–0.51) |
| Left hippocampus | 0.02 (0.00–0.08) | 0.56 (0.41–0.69) | 0.42 (0.29–0.58) |
CI = confidence interval.
↵* Parameters for schizophrenia are fixed based on the genetic point estimates of meta-analysis results (h2 = 0.81, χ2 = 0.11, e2 = 0.08) and the thresholds on the liabilities are fixed to reflect a prevalence of 1%.
↵† h2, χ2 and e2 are the heritability, shared and nonshared environmental influences, the standardized variance component due to A, C and E factors.