Regression models predicting CBT outcome in patients with OCD (n = 73) with basolateral amygdala–ventromedial prefrontal cortex resting-state functional connectivity as a predictor
| Binomial logistic regression model: CBT response (yes v. no) | Multiple regression model: post-CBT YBOCS | |||||
|---|---|---|---|---|---|---|
| Predictor | Wald test | OR* (95% CI) | p value | B | t (95% CI) | p value |
| Sex | 2.566 | 1.197 (0.961 to 1.491) | 0.11 | −0.413 | −2.109 (−0.799 to −0.022) | 0.039 |
| Age | 1.111 | 1.007 (0.994 to 1.020) | 0.29 | −0.008 | −0.691 (−0.031 to −0.015) | 0.49 |
| Baseline YBOCS score | 5.407 | 0.968 (0.942 to −0.995) | 0.020 | 0.212 | 9.119 (0.166 to −0.251) | < 0.001 |
| Baseline HAMD score | 0.29 | 0.997 (0.962 to 1.034) | 0.87 | 0.001 | 0.023 (−0.063 to −0.065) | 0.98 |
| BLA–vmPFC rs-fc | 5.246 | 0.494 (0.280 to −0.903) | 0.022 | 1.524 | 3.095 (0.541 to 2.507) | 0.003 |
BLA–vmPFC rs-fc = basolateral amygdala–ventromedial prefrontal cortex resting-state functional connectivity; CBT = cognitive behavioural therapy; CI = confidence interval; HAMD = Hamilton Rating Scale for Depression; OCD = obsessive–compulsive disorder; OR = odds ratio; YBOCS = Yale–Brown Obsessive Compulsive Scale.
↵* OR and multiple regression coefficients are reported for one standard deviation increase in the predictor.