Table 3

Brain regions reaching statistical significance for each analysis of interest*

MNI coordinates
Brain regionLat.Cluster size (k)xyzt value
Pain > no pain: controls ∩ patients
 Superior parietal sulcusR75016−72526.4
 Superior occipital gyrusR26−64344.71
 Superior parietal sulcus/precuneusR14−70424.49
 Inferior occipital/occipito-temporal cortexL233−50−68−44.65
 Cerebellum (crus1)R370736−54−327.41
 Cerebellum (crus1)L−40−56−327.2
 Cerebellum (declive 6)R28−66−307.18
 Inferior parietal/intraparietal sulcusL3862−46−36448.33
 Inferior parietal/supramarginal gyrusL−54−26348.12
 Superior parietal sulcusL−22−66588.01
 Inferior parietal/supramarginal gyrusR238654−32467.91
 Inferior parietal/intraparietal sulcusR44−36407.27
 Inferior parietal/posterior parietal gyrusR48−40507.19
 Anterior insula/inferior frontal cortexL22 920−3614−410.45
 Supplementary motor areaR210609.46
 Anterior middle cingulate cortexR416448.98
Pain > no pain: controls > patients
 Anterior middle cingulate cortex/anterior cingulate cortexR24616383.56
PO1 > PS1: controls > patients
  • L = left; MNI = Montreal Neurological Institute; pSTS = posterior superior temporal sulcus; R = right; TPJ = temporoparietal junction.

  • * The threshold used for significance was p < 0.001, uncorrected, with k = 90. A less conservative threshold (k = 10) was used for regions with a priori hypotheses (middle cingulate cortex, bilateral anterior insula and TPJ).