Brain regions reaching statistical significance for each analysis of interest*
| MNI coordinates | ||||||
|---|---|---|---|---|---|---|
| Brain region | Lat. | Cluster size (k) | x | y | z | t value |
| Pain > no pain: controls ∩ patients | ||||||
| Superior parietal sulcus | R | 750 | 16 | −72 | 52 | 6.4 |
| Superior occipital gyrus | R | 26 | −64 | 34 | 4.71 | |
| Superior parietal sulcus/precuneus | R | 14 | −70 | 42 | 4.49 | |
| Inferior occipital/occipito-temporal cortex | L | 233 | −50 | −68 | −4 | 4.65 |
| Cerebellum (crus1) | R | 3707 | 36 | −54 | −32 | 7.41 |
| Cerebellum (crus1) | L | −40 | −56 | −32 | 7.2 | |
| Cerebellum (declive 6) | R | 28 | −66 | −30 | 7.18 | |
| Inferior parietal/intraparietal sulcus | L | 3862 | −46 | −36 | 44 | 8.33 |
| Inferior parietal/supramarginal gyrus | L | −54 | −26 | 34 | 8.12 | |
| Superior parietal sulcus | L | −22 | −66 | 58 | 8.01 | |
| Inferior parietal/supramarginal gyrus | R | 2386 | 54 | −32 | 46 | 7.91 |
| Inferior parietal/intraparietal sulcus | R | 44 | −36 | 40 | 7.27 | |
| Inferior parietal/posterior parietal gyrus | R | 48 | −40 | 50 | 7.19 | |
| Anterior insula/inferior frontal cortex | L | 22 920 | −36 | 14 | −4 | 10.45 |
| Supplementary motor area | R | 2 | 10 | 60 | 9.46 | |
| Anterior middle cingulate cortex | R | 4 | 16 | 44 | 8.98 | |
| Pain > no pain: controls > patients | ||||||
| Anterior middle cingulate cortex/anterior cingulate cortex | R | 24 | 6 | 16 | 38 | 3.56 |
| PO1 > PS1: controls > patients | ||||||
| TPJ/pSTS | R | 35 | 46 | −44 | 14 | 4.33 |
| TPJ/pSTS | L | 92 | −44 | −42 | 12 | 4.47 |
| TPJ/pSTS | L | −44 | −38 | 4 | 3.84 | |
L = left; MNI = Montreal Neurological Institute; pSTS = posterior superior temporal sulcus; R = right; TPJ = temporoparietal junction.
↵* The threshold used for significance was p < 0.001, uncorrected, with k = 90. A less conservative threshold (k = 10) was used for regions with a priori hypotheses (middle cingulate cortex, bilateral anterior insula and TPJ).