Table 2

Results of the group (MDD, HC) × FH (FH+, FH−) analysis of variance for the analysis of psychophysiological interactions with the medial OFC as seed region (x, y, z = 6, 52, −12)^*

Interaction; region	Cluster size (k)	MNI (at peak)			Side	F₉₆	z-score

		x	y	z
Group × family history interaction
Middle occipital gyrus/inferior occipital gyrus	138	36	−88	4	R	19.90	4.09
Main effect of group
Supramarginal gyrus/inferior parietal gyrus/postcentral gyrus	550	62	−24	30	R	32.28	5.13
Inferior parietal gyrus	143	−40	−46	48	L	27.70	4.78
Superior frontal gyrus/middle frontal gyrus	304	−18	4	68	L	27.34	4.75
Inferior parietal gyrus/supramarginal gyrus	164	−62	−44	42	L	26.47	4.68
Insula/putamen	153	38	12	2	R	23.08	4.38
Superior frontal gyrus/middle frontal gyrus	244	26	2	60	R	22.70	4.35
Superior parietal gyrus/precuneus	158	−16	−66	50	L	21.18	4.21
Middle frontal gyrus/superior frontal gyrus	103	26	56	36	R	16.85	3.76
Main effect of family history
Middle occipital gyrus/inferior occipital gyrus/superior occipital gyrus	272	28	−94	4	R	28.66	4.86
Supramarginal gyrus/rolandic operculum	93	52	−28	24	R	22.91	4.37

FH+ = positive family history of MDD; FH− = no family history of MDD; HC = healthy controls; MDD = major depressive disorder; MNI = Montreal Neurological Institute; OFC = orbitofrontal cortex.
↵* All whole brain analyses with a voxel threshold of p < 0.001, minimum cluster volume threshold of k ≥ 89.