Neurofunctional abnormalities underlying clinical vulnerability to psychosis
| Comparison; brain region | Side | BA | Peak local maximum | |||||
|---|---|---|---|---|---|---|---|---|
| Coordinate | SDM | p value | Ke | |||||
| x | y | z | ||||||
| Controls > high-risk | ||||||||
| MFG | L | 8 | −4 | 26 | 44 | 0.323 | < 0.001 | 292 |
| MFG | L | 8 | 59 | |||||
| Cingulus gyrus | L | 32 | 31 | |||||
| SFG | L | 8 | 52 | |||||
| SFG | R | 8 | 41 | |||||
| MFG | R | 8 | 22 | |||||
| SFG | L | 6 | 43 | |||||
| SFG | R | 6 | 29 | |||||
| IFG | L | 9 | 76 | |||||
| IFG | L | 9 | −46 | 16 | 22 | 0.275 | < 0.001 | 36 |
| High-risk > controls | — | — | — | |||||
BA = Brodmann area; IFG = inferior frontal gyrus; Ke = cluster extent; L = left; MFG = medial frontal gyrus; R = right; SDM = signed differential mapping; SFG = superior frontal gyrus.