Regions of fractional anisotropy and mean diffusivity abnormalities in patients with obsessive–compulsive disorder and healthy controls (p < 0.01, corrected)
| Region of interest; area | Hemisphere | Changes in patients compared with controls | MNI coordinate | Group; mean (SD) value | p value | |||
|---|---|---|---|---|---|---|---|---|
| x | y | z | Control | OCD | ||||
| Anterior limb of internal capsule | ||||||||
| NA | Right | ↓ Fractional anisotropy | 70 | 145 | 74 | 0.436 (0.047) | 0.393 (0.034) | 0.008 |
| NA | Right | ↑ Fractional anisotropy | 72 | 137 | 80 | 0.633 (0.043) | 0.683 (0.044) | 0.002 |
| NA | Left | ↑ Fractional anisotropy | 106 | 135 | 80 | 0.672 (0.045) | 0.717 (0.064) | 0.009 |
| Cingulum | ||||||||
| Anterior cingulum | Left | ↓ Mean diffusivity | 100 | 159 | 85 | 9.38E10−4 (1.13E10−4) | 8.19E10−4 (1.15E10−4) | 0.002 |
| Body of the cingulum | Right | ↓ Mean diffusivity | 83 | 117 | 107 | 8.12E10−4 (5.5E10−5) | 7.70E10−4 (4.1E10−5) | 0.002 |
MNI = Montreal Neurological Institute; NA = not applicable; OCD = obsessive–compulsive disorder; SD = standard deviation.