Behavioural differences between the study groups: patients versus healthy controls; family history of major depressive disorder versus no family history of major depressive disorder; post hoc analysis of differences between individual pairs of groups
| Group, mean (SD) | |||
|---|---|---|---|
| Group; contrast | Group 1 | Group 2 | p value, intergroup difference |
| MDD (n = 50) v. healthy controls (n = 46) | |||
| Emotion processing condition accuracy | 74.8 (12.8) | 82.9 (9.4) | 0.001 |
| Emotion processing condition reaction time | 1.51 (0.44) | 1.33 (0.31) | 0.020 |
| Attention shifting condition accuracy | 77.6 (16.6) | 88.7 (11.1) | < 0.001 |
| Attention shifting condition reaction time | 1.65 (0.43) | 1.3 (0.27) | < 0.001 |
| Family history of MDD (n = 51) v. no family history of MDD (n = 45) | |||
| Emotion processing condition accuracy | 78.5 (12.6) | 79.1 (11.2) | 0.82 |
| Emotion processing condition reaction time | 1.41 (0.44) | 1.44 (0.33) | 0.73 |
| Attention shifting condition accuracy | 81.9 (15.8) | 84.3 (14.4) | 0.44 |
| Attention shifting condition reaction time | 1.53 (0.45) | 1.42 (0.34) | 0.18 |
| HC-FHP (n = 21) v. HC-FHN (n = 25) | |||
| Emotion processing condition accuracy | 82.9 (11.6) | 82.9 (7.3) | > 0.99 |
| Emotion processing condition reaction time | 1.27 (0.26) | 1.37 (0.35) | 0.84 |
| Attention shifting condition accuracy | 89.9 (11.5) | 87.6 (10.8) | 0.94 |
| Attention shifting condition reaction time | 1.28 (0.22) | 1.32 (0.32) | > 0.99 |
| HC-FHP (n = 21) v. MDD-FHP (n = 30) | |||
| Emotion processing condition accuracy | 82.9 (11.6) | 75.4 (12.6) | 0.11 |
| Emotion processing condition reaction time | 1.27 (0.26) | 1.5 (0.51) | 0.17 |
| Attention shifting condition accuracy | 89.9 (11.5) | 76.3 (16.1) | 0.006 |
| Attention shifting condition reaction time | 1.28 (0.22) | 1.71 (0.48) | < 0.001 |
| HC-FHN (n = 25) v. MDD-FHN (n = 20) | |||
| Emotion processing condition accuracy | 82.9 (7.3) | 73.8 (13.5) | 0.05 |
| Emotion processing condition reaction time | 1.37 (0.35) | 1.53 (0.29) | 0.50 |
| Attention shifting condition accuracy | 87.6 (10.8) | 79.8 (17.6) | 0.29 |
| Attention shifting condition reaction time | 1.32 (0.32) | 1.56 (0.32) | 0.15 |
| MDD-FHP (n = 30) v. MDD-FHN (n = 20) | |||
| Emotion processing condition accuracy | 75.4 (12.6) | 73.8 (13.5) | 0.96 |
| Emotion processing condition reaction time | 1.5 (0.51) | 1.53 (0.29) | 0.99 |
| Attention shifting condition accuracy | 76.3 (16.1) | 79.8 (17.6) | 0.84 |
| Attention shifting condition reaction time | 1.71 (0.48) | 1.56 (0.32) | 0.51 |
| 4-way analysis of variance | |||
| Emotion processing condition accuracy | 4 | 3 | 0.010 |
| Emotion processing condition reaction time | 2.1 | 3 | 0.11 |
| Attention shifting condition accuracy | 5.1 | 3 | 0.003 |
| Attention shifting condition reaction time | 8.1 | 3 | < 0.001 |
Accuracy = percentage of correct answers; HC-FHN = healthy controls without family history of MDD; HC-FHP = healthy controls with a family history of MDD; MDD = major depressive disorder; MDD-FHN = patients with MDD without family history of MD; MDD-FHP = patients with MDD with a family history of MDD; SD = standard deviation.