Characteristics of healthy controls, people at clinical high risk for schizophrenia and medication-naive patients with schizophrenia*
| Group; mean (SD)† | |||
|---|---|---|---|
| Characteristic | Control, n = 12 | CHR, n = 12 | Schizophrenia, n = 13 |
| Age, yr | 26.1 (3.8) | 23.00 (4.6) | 23.38 (4.6) |
| Sex, no. | |||
| Female | 5 | 5 | 3 |
| Male | 7 | 7 | 10 |
| [11C]-(+)-PHNO | |||
| Amount injected | 8.97 (1.66) | 9.17 (2.15) | 9.41 (1.30) |
| Specific activity | 1019.76 (453.50) | 1014.84 (434.26) | 1076.51 (477.06) |
| Mass injected | 2.28 (0.75) | 2.58 (0.90) | 2.43 (0.75) |
| SOPS-P score | NA | 11.25 (2.90) | NA |
| PANSS-P score | NA | NA | 18.92 (4.48) |
| Mean task completion | 44.23 (12.15) | 24.52 (15.08) | 24.59 (16.43) |
| Mean task errors | 5.23 (3.38) | 5.16 (3.38) | 8.86 (8.03) |
| Smoking status, no. | |||
| Nonsmoker | 11 | 11 | 7 |
| Smoker | 1 | 1 | 6 |
| Cannabis use, no. | |||
| No | 0 | 0 | 9 |
| Yes | 0 | 0 | 4 |
CHR = clinical high risk for schizophrenia; NA = not applicable; P = positive; PANSS = Positive and Negative Symptom Scale; (29) SD = standard deviation; SOPS = Scale for the Assessment of Prodromal Symptoms. (26)
↵* There was no difference among the groups in any variable, except mean task completion (F2,36 = 7.23, p = 0.002), and there were trend-level differences for smoking status (Fisher exact test = 5.76; p = 0.06) and cannabis use (Fisher exact test = 4.19, p = 0.09).
↵† Unless otherwise indicated.