Dose-dependent change in corrected QT interval for citalopram and escitalopram*
| Medication | Dose | Change in QTc (95% CI), ms |
|---|---|---|
| Citalopram | 20 mg | 8.5 (6.2–10.8) |
| 40 mg† | 12.6 (10.9–14.3) | |
| 60 mg | 18.5 (16.0–21.0) | |
| Escitalopram | 10 mg | 4.5 (2.5–6.4) |
| 20 mg† | 6.6 (5.3–7.9) | |
| 30 mg | 10.7 (8.7–12.7) |
CI = confidence interval; QTc = corrected QT interval.
↵* Revised Mar. 27, 2012, to include escitalopram.
↵† Estimate based on the relationship between blood concentrations and QT interval.
Source: www.fda.gov/drugs/drugsafety/ucm297391.htm (accessed 2012 Dec. 19).