Examples of central nervous system–acting endogenous substrates of cytochromes P45013–15,19
| Enzyme | Substrate | Metabolite |
|---|---|---|
| CYP1A1 | Melatonin, estradiol, arachidonic acid, progesterone, all-trans-retinal | 6-hydroxymelatonin, 2-hydroxyestradiol, 16–19 HETE, 16β-hydroxyprogesterone, retinol, all-trans-retinoic acid |
| CYP1B1 | Melatonin, estradiol | 6-hydroxymelatonin, 2-hydroxyestradiol |
| CYP2B | Arachidonic acid, testosterone, serotonin, anandamide, all-trans-retinoic acid | 20,19 HETE, 16α-hydroxytestosterone, hydroxylamine, nitric oxide, 11,12-EET-EA, 4-hydroxyretinoic acid, 4-oxoretinoic acid |
| CYP2C | Testosterone, progesterone, arachidonic acid, serotonin, harmaline, harmine, linoleic acid, melatonin, all-trans-retinoic acid | 11 β-hydroxytestosterone, 21-hydroxyprogesterone, EETs, 19 HETE, hydroxylamine, nitric oxide, harmalol, harmol, 11-hydroxyoctadecadienoic acid, 6-hydroxyserotonin, N-acetylserotonin, 18-hydroxyretinoic acid |
| CYP2D | 5-methoxytryptamine, octopamine, synephrine, tyramine, progesterone, anandamide, harmaline, harmine | Serotonin, noradrenaline, adrenaline, dopamine, 11-deoxycorticosterone, 16α-, 16β-, 17β-, 2β-, 6β-hydroxyprogesterone, 20-HETE-EA, harmalol, harmol |
| CYP2E1 | Arachidonic acid, linoleic acid, oleic acid | 18,19-HETE, hydroxylinoleic acid, 17-, 18-hydroxyoleic acid |
EA = ethanolamide; EET = epoxyeicosatrienoic acids; HETE = hydroxyeicosatetraenoic acid.