Table 2

Neural regions demonstrating significant BOLD differences between patients with bvFTD and healthy controls during emotional face processing

Facial expression; group contrast; brain region^*	BA	Volume, mm³	MNI coordinate			t value

			x	y	z
Angry expressions
bvFTD < controls
Right inferior frontal gyrus	47	189	23	9	−22	−3.78
Left fusiform gyrus	37	675	−35	−51	−14	−3.18
Right cuneus	17	324	23	−89	8	−3.43
bvFTD > controls
Left posterior cingulate gyrus	31	351	−2	−46	26	3.12
Right inferior parietal lobule	39	270	38	−62	32	3.66
Disgusted expressions
bvFTD < controls
Right insula	13	432	38	14	7	−3.21
Left insula	13	270	−35	23	4	−3.49
Left lingual/fusiform gyrus	18	324	−20	−73	−5	−3.41
Right middle occipital gyrus	18	351	23	−89	11	−3.12
Happy expressions
bvFTD < controls
Left amygdala^†	NA	648	−26	−4	−26	−2.31
bvFTD > controls
Right inferior parietal lobule	39	432	41	−69	38	3.05
Fearful expressions
bvFTD < controls
Left medial frontal gyrus	6	270	−2	−4	52	−3.26
Left lingual/fusiform gyrus	18	216	−5	−91	−17	−3.60
Left middle occipital gyrus	18	216	−20	−92	11	−3.23
Right cuneus	17	432	23	−89	8	−3.25
Sad expressions
bvFTD < controls
Left anterior cingulate gyrus	6/24	459	−2	7	51	−4.04
Left lingual/fusiform gyrus	18	270	−17	73	−5	−3.08
Right insula	13	243	44	−14	8	−4.03
Right cuneus	17	324	23	−89	8	−3.45
Left precuneus	7	324	−8	−81	44	−3.12
Right superior frontal gyrus	9	297	32	49	35	−3.27
Right inferior parietal lobule	40	297	41	34	34	−3.46

BA = Brodmann area; BOLD = blood oxygen level–dependent; bvFTD = behavioural variant frontotemporal dementia; MNI = Montreal Neurological Institute.
↵* All regions were corrected for whole-brain voxel-wise grey matter volumes. Hemispheric location, BA, volume, MNI coordinates at the centre of peak activation and maximum activity (t value) for each significant cluster are shown. Functional threshold was set at p < 0.005; p < 0.05, corrected.
↵† p < 0.05; p < 0.05, small-volume corrected.