Genotype; amygdala location | SAD group | Control group | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistics | MNI coordinates | Statistics | MNI coordinates | |||||||||
No. | p value | z score | x | y | z | No. | p value | z score | x | y | z | |
5-HTTLPR/s > ll | 16/18 | 9/9 | ||||||||||
Left | 0.013 | 3.04 | −26 | 2 | −20 | > 0.10 | ||||||
Right | > 0.10 | 0.014* | 2.19 | 22 | −8 | −10 | ||||||
TPH2/T > GG | 13/21 | 6/12 | ||||||||||
Left | 0.006 | 3.33 | −24 | −8 | −22 | 0.030* | 1.88 | −16 | −6 | −14 | ||
Right | > 0.10 | > 0.10 | ||||||||||
At least 1 high/ both low | 22/12 | 12/6 | ||||||||||
Left | 0.010* | 2.33 | −26 | 2 | −20 | 0.016* | 2.14 | −20 | −2 | −14 | ||
Right | > 0.10 | 0.041 | 2.58 | 18 | −6 | −14 | ||||||
Both high/> 1 high | 7/15 | |||||||||||
Left | 0.024 | 2.82 | −22 | −8 | −22 | |||||||
Right | > 0.10 | |||||||||||
Both high/both low | 7/12 | |||||||||||
Left | 0.025 | 2.80 | −22 | −4 | −26 | |||||||
Right | > 0.10 |
5-HTTLPR = serotonin transporter promoter polymorphic region (s = short allele carriers, ll = homozygous for long allele); high = high-response alleles (s, T); low = low-response alleles (ll, GG); MNI = Montreal Neurological Institute; SAD = social anxiety disorder; TPH2 = tryptophan hydroxylase-2 polymorphism (T allele carriers or GG = homozygous for G allele).
↵* Uncorrected for multiple comparisons.