Table 2

Amygdala reactivity (angry > neutral faces) in genetic subgroups of patients with social anxiety disorder and controls

Genotype; amygdala locationSAD groupControl group
StatisticsMNI coordinatesStatisticsMNI coordinates
No.p valuez scorexyzNo.p valuez scorexyz
5-HTTLPR/s > ll16/189/9
 Left0.0133.04−262−20> 0.10
 Right> 0.100.014*2.1922−8−10
TPH2/T > GG13/216/12
 Left0.0063.33−24−8−220.030*1.88−16−6−14
 Right> 0.10> 0.10
At least 1 high/ both low22/1212/6
 Left0.010*2.33−262−200.016*2.14−20−2−14
 Right> 0.100.0412.5818−6−14
Both high/> 1 high7/15
 Left0.0242.82−22−8−22
 Right> 0.10
Both high/both low7/12
 Left0.0252.80−22−4−26
 Right> 0.10

  • 5-HTTLPR = serotonin transporter promoter polymorphic region (s = short allele carriers, ll = homozygous for long allele); high = high-response alleles (s, T); low = low-response alleles (ll, GG); MNI = Montreal Neurological Institute; SAD = social anxiety disorder; TPH2 = tryptophan hydroxylase-2 polymorphism (T allele carriers or GG = homozygous for G allele).

  • ↵* Uncorrected for multiple comparisons.