Table 1

Structural imaging studies that have correlated brain morphology with cognitive performance in Huntington’s disease

StudySubjectsImaging technique/procedureCognitive tasksEvidence of correlation?*Comments and additional findings
StriatumFrontal lobeTemporal lobe
Bamford et al (27)60 HCTWAIS, TMT, Stroop, Porteus Mazes, PVT, RSPMYesN/AN/AAtrophy in striatum corr. with attention, working memory and executive functions
Harris et al (37)15 H
19 C
MRIMMSEYesN/AN/AAtrophy in caudate corr. with MMSE
Harris et al (29)10 H
9 C
MMSE, WCST, TMT, Stroop, Digit Span, Luria, BVRTYesN/AN/ACaudate volume and thalamus rCBF corr. with MMSE Global atrophy corr. with TMT
Aylward et al (30)20 H
20 C
MRI (1.5 T)
Manual tracing
MMSE, WAIS, TMT, Stroop, COWA, DTVMI, BTA, HVLT, BVRTNoYesN/ASmaller total brain, frontal lobe and frontal white matter. Frontal lobe volume corr. with MMSE and verbal and spatial ability
Kassubek et al (33)44 H
22 C
MRI (1.5 T)
COWA, Stroop, WAISYesN/AN/ADecreases of grey matter of the thalamus corr. with COWA and Stroop
  • BTA = Brief Test of Attention; BVRT = Benton Visual Retention Test; C = controls; corr. = correlated; COWA = Control Oral Word Association; CT = computed tomography; Digit Span = Digit-Span Memory Test; DTVMI = Developmental Test of Visual Motor Integration; H = subjects with Huntington’s disease; HVLT = Hopkins Verbal Learning Test; Luria = Luria Sequential Hand Positions Tests; MMSE = Mini-Mental State Examination; MRI = magnetic resonance imaging; PPVT = Peabody Picture Vocabulary Test; rCBF = regional cerebral blood flow; RSPM = Raven’s Standard Progressive Matrices; SPECT = single-photon emission computed tomography; Stroop = Stroop Test; TMT = Trail-Making Test; VBM = voxel-based morphometric analysis; WAIS = Wechsler Adult Intelligence Scale; WCST = Wisconsin Card Sorting Test.

  • * N/A = region not assessed; Yes = correlation; No = no correlation.