Table 1

Decreases in metabolism after risperidone, 2 mg, in healthy subjects

Location of decrease in metabolism	Talairach coordinates of the most significant change	Peak z^*	Uncorrected p value for peak z	Corrected p value for peak z^†	Cluster size (voxels)^‡	p value for cluster size^§
Left lateral frontal cortex	−48, 38, 28	3.88	< 0.001	0.039	338	0.038
Right medial frontal cortex	14, 42, 32	3.57	< 0.001	0.11	125	0.22

↵* The peak z is the z score corresponding to the t statistic for the difference in the specified voxel.
↵† The corrected p value represents the probability of observing a change as large as that observed under the null hypothesis, after correcting for multiple comparisons.
↵‡ The cluster size is the number of contiguous voxels in which the uncorrected p value for the observed z value is less than 0.05.
↵§ The p value for cluster size represents the probability of observing a cluster as large as the observed cluster under the null hypothesis.