Table 1

Decreases in metabolism after risperidone, 2 mg, in healthy subjects

Location of decrease in metabolismTalairach coordinates of the most significant changePeak z*Uncorrected p value for peak zCorrected p value for peak zCluster size (voxels)p value for cluster size§
Left lateral frontal cortex−48, 38, 283.88< 0.0010.0393380.038
Right medial frontal cortex14, 42, 323.57< 0.0010.111250.22
  • * The peak z is the z score corresponding to the t statistic for the difference in the specified voxel.

  • The corrected p value represents the probability of observing a change as large as that observed under the null hypothesis, after correcting for multiple comparisons.

  • The cluster size is the number of contiguous voxels in which the uncorrected p value for the observed z value is less than 0.05.

  • § The p value for cluster size represents the probability of observing a cluster as large as the observed cluster under the null hypothesis.