Table 2

Sites identified by conjunction analysis at which both healthy subjects and patients with schizophrenia exhibited a decrease in metabolism after risperidone, 2 mg

Location of decrease in metabolism	Talairach coordinates of the most significant change	Peak z	Uncorrected p value for peak z^*	Corrected p value for peak z^†	Cluster size (voxels)^‡	p value for cluster size^§
Left lateral frontal cortex	−46, 44, 2	4.54	< 0.001	0.002	2599	0.031
Right medial frontal cortex	18, 44, 32	3.75	< 0.001	0.039	415	0.43x

↵* The uncorrected p value represents the joint probability of a change as large as the observed change in the specified voxel under the null hypothesis.
↵† The corrected p value represents the probability after correcting for multiple comparisons.
↵‡ Cluster size refers to the number of contiguous voxels in which the joint p value is less than 0.05.
↵§ The p value for cluster size represents the probability of observing a cluster as large as the observed cluster under the null hypothesis.