Reduction of immobility time in the FST with imipramine, 8 mg/kg, or fluoxetine, 16 mg/kg, in interaction with serotonin receptor agonists/antagonists in mice after acute administration (n = 10/group)
| Treatment | Mean immobility time (and SEM), s [and % of change from drug alone] | Mean (and SEM) immobility time of distilled-water controls, s |
|---|---|---|
| Imipramine + pindolol | 185 (11) [25] | 227 (3) |
| Imipramine + 8-OH-DPAT | 179 (20) [18]* | 223 (5) |
| Fluoxetine + pindolol | 121 (14) [43]† | 229 (3) |
| Fluoxetine + 8-OH-DPAT | 219 (6) [5] | 234 (2) |