Reduction of immobility time in the forced swimming test (FST) with S 20098 alone or in interaction with serotonin receptor agonists/antagonists in mice (n = 10/group) after acute administration
| Treatment | Treatment; mean reduction of immobility time (and SEM), s [and % of reduction compared with controls] | Mean immobility time (and SEM), s | ||||
|---|---|---|---|---|---|---|
| S 20098, 4 mg/kg | S 20098, 8 mg/kg | S 20098, 16 mg/kg | S 20098, 32 mg/kg | S 20098, 64 mg/kg | Controls | |
| S 20098 | 219 (17) | 230 (6) | 221 (6) | 215 (17) | 222 (13) | 226 (12) |
| S 20098 + 8-OH-DPAT | 208 (15) | 202 (28) [13]* | 202 (28) | 195 (23) [9]* | 217 (13) | 226 (14) |
| S 20098 | 227 (11) | NA | 235 (2.3) | NA | 215 (15) | 230 (6) |
| S 20098 + pindolol | 205 (16) [10]* | NA | 173 (18) [27]* | NA | 160 (22) [23]* | 230 (8) |
| S 20098 + anpirtoline | 220 (14) | NA | 211 (19) [10]* | NA | 185 (20) [13]* | 231 (5) |
| S 20098 | 234 (4) | NA | 229 (6) | NA | 227 (9) | 232 (4) |
| S 20098 + ritanserin | 220 (10) | NA | 203 (21) [11]* | NA | 210 (13) [7]* | 227 (14) |
| S 20098 + ondansetron | 192 (20) [18]* | NA | 174 (34) [24]* | NA | 204 (13) [10]* | 224 (14) |
Note SEM = standard error of the mean; NA = not assessed.
↵* Statistically significant data (nonparametric Kruskal–Wallis H test, post hoc Steel test).