Table 1

Expression of mRNA levels for selected hippocampal proteins on postnatal day (PND) 10 by DNA membrane microarray^*

Gene	Optical density		Change in optical density (Group 2/1)	Optical density		Change in optical density (Group 4/3)

	Vehicle (Group 1)^†	Leptin (Group 2)^†		NSS (Group 3)^‡	Lept-AB (Group 4)^‡
GluT and GluT-R glutamate transporter	34	167	4.93	63^§	34	0.54
Myelin proteolipid protein (PLP)	180	684	3.79	81^§	37	0.45
Synapsin 2A	315	947	3.00	230	79	0.34
Synaptophysin, p38	387	868	2.24	228^§	46	0.20
Glutamate receptor 2 precursor	306	680	2.22	319	274	0.86
Synaptosomal associated protein 25 (SNAP-25)	836	1813	2.17	462	269	0.58
Insulin-like growth factor–binding protein 5 precursor (IGF-binding protein 5 [IGFBP5, IBP5])	165	52	0.32	54^§	41	0.75
Neuropeptide Y5 receptor	144	45	0.31	51^§	49	0.96
Insulin-like growth factor II (IGF-II)	495	78	0.16	428^§	84	0.20
Neuromodulin, axonal membrane protein GAP43	3202	2229	0.70	918	534	0.58
Synaptobrevin 2 (SYB2), (VAMP2)	418	643	1.54	135	30	0.22
N-methyl-d-aspartate receptor (NMDAR1), NR1	ND	ND		ND	ND
NMDAR2B (NR2B)	773	752	0.97	79	47	0.59
NMDAR2A (NR2A)	93	159	1.71	ND	ND

Note: Lept-AB = leptin antiserum; ND = not detected; NSS = normal sheep serum.
↵* All data from 4 days’ exposure to radiographic film. Results obtained for all groups on membranes exposed for 20–24 h.
↵† Rats received daily vehicle or leptin injections (3 mg/kg body weight, intraperitoneally) during PND 2–9 (groups 1 and 2).
↵‡ Rats received daily NSS or Lept-AB during PND 2–9 (groups 3 and 4).
↵§ Results obtained on membranes exposed for 18 d.