Table 1

Magnetic resonance imaging studies of hippocampal volume in depression

Study	Statistically significant changes in HC volume	Mean age, yr	Patients			Controls

			No. of subjects	Mean hippocampal volume, mm³		No. of subjects	Mean hippocampal volume, mm³

				L	R		L	R
Posener et al70	No	33	27	2546	2948	42	2475	2994
MacQueen et al23
Multiple past episodes of depression	↓L and R	32	17	2381	2392	17	2703	2692
First episode of depression	No	28	20	2738	2793	20	2761	2784
Vythilingam et al24
Past abuse	↓L	33	21	2705	2690	14	3179	3037
No past abuse	No	34	11	3292	3078	14	3179	3037
Frodl et al25	↓L^*	40	30	3564	3745	30	3616	3641
Rusch et al71	No	33	25	2170	2290	15	2130	2200
Steffens et al26	↓R	72	66	2920	2980	18	3170	3300
Bremner et al72	↓L	43	16	940	982	16	1166	1113
Mervaala et al27	↓L	42	34	3104	3462	17	3441	3700
Vakili et al73	No	38	38	2640	2610	20	2460	2600
Von Gunten et al74	No	58	14	2499	2598	14	2644	2700
Ashtari et al75	No	74	40	1745	1742	46	1843	1853
Sheline et al29	↓L and R	54	24	2230	2264	24	2482	2468
Sheline et al30	↓L and R	68	10	2159	2283	20	2544	2577

Note: HC = hippocampal complex; L = left; R = right.
↵* Statistically significant difference between LHC of patients and controls seen only in men.