Brain areas with significantly* increased activation in patients with schizophrenia compared with controls in the contrast of trials after negative feedback (set shift) versus positive feedback
| Brain region | Talairach coordinates | Brodmann area | Z score† | No. of voxels | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Right hemisphere | ||||||
| Anterior cingulate gyrus | 10 | 41 | 11 | 32 | 3.60 | 23 |
| Anterior cingulate gyrus | 10 | 45 | 1 | 32 | 4.00 | 91‡ |
| Superior temporal gyrus | 61 | −32 | 15 | 22 | 3.62 | 10 |
| Left hemisphere | ||||||
| Superior temporal gyrus | −44 | −36 | 17 | 41 | 4.18 | 53§ |
| Insula | −38 | −18 | −8 | 13 | 3.73 | 25 |
↵* Determined by 2-sample t test, p < 0.001, uncorrected. Controls revealed no areas of increased brain activation compared with schizophrenia patients.
↵† Expressed as the maximum within each area. Local maxima are separated by a minimum of 8 mm.
↵‡ Cluster-level correction (p < 0.005) for multiple comparisons.
↵§ Cluster-level correction (p < 0.05) for multiple comparisons.