Brain areas with significantly increased activation in patients with schizophrenia compared with controls in the analysis of matching after negative feedback (set-shifting) versus positive feedback
| Brain region | Talairach coordinates | Brodmann area | Z score* | No. of voxels | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Right hemisphere | ||||||
| Anterior cingulate gyrus | 12 | 44 | −10 | 32 | 3.52 | 18 |
| Inferior frontal gyrus | 28 | 31 | −12 | 47 | 4.69 | 48† |
| Inferior frontal gyrus | 42 | 37 | 7 | 46 | 3.55 | 26 |
| Caudate nucleus | 18 | 23 | 1 | — | 3.50 | 34 |
| Left hemisphere | ||||||
| Anterior cingulate gyrus | −12 | 27 | 28 | 32 | 3.92 | 56‡ |
| Cingulate gyrus | −16 | −31 | 37 | 31 | 3.78 | 20 |
| Caudate nucleus | −18 | 8 | 11 | — | 3.60 | 26 |
↵* Expressed as the maximum within each area. Local maxima are separated by a minimum of 8 mm.
↵† Cluster-level correction (p < 0.05) for multiple comparisons.
↵‡ Determined by 2-sample t test, p < 0.001, uncorrected. Controls revealed no areas of increased brain activation compared with schizophrenia patients.