Comparison of change in global brain structures between patients receiving methylphenidate versus placebo after 13 weeks (3-month sample)
| Visit; mean ± SD, mm3 | |||||||
|---|---|---|---|---|---|---|---|
| Variable | Week 0 | Week 13 | Statistic | p value | |||
| Grey matter | |||||||
| MPH | 643.91 | 63.5 | 641.44 | 63.5 | Cohort | F1,96 = 0.50 | 0.44† |
| Placebo | 634.82 | 59.1 | 630.76 | 59.2 | |||
| Visit | F1,96 = 8.42; p = 0.005* | Cohort × visit | F1,95 = 0.61 | 0.48‡ | |||
| White matter | |||||||
| MPH | 520.12 | 66.1 | 522.42 | 67.4 | Cohort | F1,95 = 0.01 | 0.94† |
| Placebo | 520.81 | 61.2 | 523.63 | 62.7 | |||
| Visit | F1,96 = 11.53 ; p = 0.001* | Cohort × visit | F1,96 = 0.12 | 0.73‡ | |||
| CSF | |||||||
| MPH | 222.34 | 28.0 | 221.57 | 27.1 | Cohort | F1,95 = 1.05 | 0.31† |
| Placebo | 229.13 | 38.9 | 228.52 | 39.1 | |||
| Visit | F1,96 = 1.01; p = 0.32* | Cohort × visit | F1,96 = 0.01 | 0.91‡ | |||
CSF = cerebrospinal fluid; MPH = methylphenidate.
↵* Effect of visit in mixed-model statistic with covariate group psychotherapy versus clinical management.
↵† Effect of cohort in mixed-model statistic with covariate group psychotherapy versus clinical management.
↵‡ Cohort × visit interaction in mixed model statistic with covariate group psychotherapy versus clinical management.