Region-of-interest-based analysis for GLM-flex comparison of patients receiving methylphenidate versus placebo after 13 weeks (3-month sample) and 52 weeks (1-year sample)*
| 3-month sample | 1-year sample | |||||
|---|---|---|---|---|---|---|
| Area | Statistic | p value | p value, FDR† | Statistic | p value | p value, FDR† |
| ACC | F1,94 = 14.19 | < 0.001 | 0.999 | F2,124 = 5.67 | 0.005 | 0.99 |
| DLPFC | F1,94 = 13.39 | < 0.001 | 1.000 | F2,124 = 5.21 | 0.007 | > 0.99 |
| IPL | F1,94 = 10.07 | 0.002 | 1.000 | F2,124 = 5.77 | 0.004 | 0.91 |
| Cerebellum | F1,94 = 11.49 | 0.001 | 0.604 | F2,124 = 7.30 | 0.001 | 0.53 |
| Caudate | F1,94 = 5.75 | 0.018 | 0.975 | F2,124 = 2.57 | 0.004 | 0.99 |
| Putamen | F1,94 = 3.94 | 0.05 | 1.000 | F2,124 = 3.55 | 0.032 | > 0.99 |
ACC = anterior cingulate cortex; DLPFC = dorsolateral prefrontal cortex; FDR = false discovery rate; IPL = inferior parietal lobule.
↵* Peak voxel F and uncorrected p values for 2 × 2 × 2 mixed-effects analysis of variance for the 3-month sample and a 2 × 2 × 3 mixed-effects analysis of variance for the 1-year sample using GLM-flex toolbox for different regions of interest. No cluster filter has been applied to the uncorrected p and F values.
↵† FDR-corrected p values have been adjusted for the number of voxels in the corresponding regions of interest.