Table 3

Brain areas showing activation during presentation of the dissociation-inducing script compared with the neutral script and significant correlations between blood oxygen level–dependent signal and dissociation

Group; MNI coordinatesSideLobeGyrusBAT local maximum (voxel level)κ1-sample t test*Correlation between BOLD signal and DSS-4
BPD, n = 15
 −60624LFrontalInferior frontal95.6439DIS > neutral
 523432RFrontalMiddle frontal464.5820Neutral > DIS
 −8−670LFrontalSuperior frontal64.9783Positive
 38−2−38RTemporalMiddle temporal215.0246Negative
 46−6−36RTemporalInferior temporal204.7446Negative
BPD and PTSD, n = 10
 −16−668LFrontalSuperior frontal66.3024DIS > neutral
 44−184RInsula135.7938DIS > neutral
 −58424LFrontalInferior frontal95.3111DIS > neutral
 −42−1646LFrontalPrecentral44.9410DIS > neutral
 −58−2216LParietalPostcentral404.7816DIS > neutral
 −81238LFrontalCingulate324.8110DIS > neutral
 −8−666LFrontalMedial frontal67.4029Positive
 64−28RTemporalSuperior temporal227.3944Positive
 −42108LFrontalPrecentral446.3660Positive
 −4042LInsula135.3860Positive
 42−3418RInsula135.5211Positive
 −38284LFrontalInferior frontal474.9513Positive
 28−12−30RLimbicParahippocampal354.8311Negative
 50−4−36RTemporalInferior temporal208.5235Negative
  • BA = Brodmann area; BOLD = blood oxygen level–dependent; BPD = bipolar disorder; DIS = dissociation-inducing script; DSS-4 = Dissociation Tension Scale-acute; (25) L = left; MNI = Montreal Neurological Institute; PTSD = posttraumatic stress disorder; R = right.

  • * All p ≤ 0.001

  • Regression analyses.