Top 5 genes from a gene-based segregation test (GESE) of 34 rare variants in 14 genes under the linkage peak
| Gene | Rare variants/ segregating rare variants, n | Observed probability | p value | Weighted p value |
|---|---|---|---|---|
| NRBF2 | 1/1 | 0.00015 | 0.00051 | 0.00538 |
| PCDH15 | 10/2 | 0.00017 | 0.00774 | 0.00220 |
| ASAH2* | 1/1 | 0.00141 | 0.01275 | 0.00408 |
| ANK3 | 5/1 | 0.00454 | 0.04415 | 0.01403 |
| JMJD1C | 7/2 | 0.02067 | 0.24728 | 0.09346 |
The number of rare variants per gene relative to the number of rare variants segregating with bipolar disorder status across the 15 families with bipolar disorder (n = 117 individuals). The observed segregating probability for each gene is provided, as is the basic gene-based p value for association after simulations and the genebased p value after per-family weight corrections. Suggestive p values (< 0.1) are reported.
↵* Genes not expressed in the brain (defined by reads per kilobase per million [RPKM] < 1 in developmental transcriptomics RNA sequence data, representing 65% of mapped genes).