Table 3

Partial correlations between alterations in white matter integrity and clinical variables in patients with major psychiatric disorders

Clinical variable	White matter A		White matter B		White matter C

	r	p value	r	p value	r	p value
Hamilton Depression Rating Scale
Somatic anxiety (factor) score	0.109	0.005^*	0.127	0.001^*	0.102	0.009^*
Psychic anxiety (factor) score	0.066	0.10	0.04	0.31	0.078	0.048^†
Core depressive (factor) score	0.059	0.13	0.053	0.17	0.073	0.06
Anorexia (factor) score	0.063	0.11	0.074	0.06	0.065	0.10
Total score	0.098	0.013^*	0.097	0.013^*	0.105	0.007^*
Hamilton Anxiety Rating Scale, total score	0.09	0.027^†	0.1	0.013^*	0.078	0.054
Young Mania Rating Scale, total score	−0.038	0.35	−0.047	0.25	0.019	0.63
Brief Psychiatric Rating Scale
Anxiety and depression (factor), score	0.07	0.10	0.065	0.13	0.046	0.29
Lack of energy (factor), score	−0.025	0.56	−0.094	0.028^†	−0.068	0.11
Thought disorder (factor), score	−0.003	0.95	−0.078	0.07	−0.007	0.88
Activity (factor), score	0.004	0.92	−0.043	0.32	0.029	0.50
Hostility (factor), score	−0.003	0.95	−0.058	0.18	−0.002	0.97
Total score	0.019	0.66	−0.051	0.23	−0.001	0.99
Wisconsin Card Sorting Test
Corrected responses	0.074	0.11	0.064	0.16	0.071	0.12
Categories completed	0.114	0.014^†	0.123	0.008^*	0.11	0.017^†
Total errors	−0.061	0.19	−0.062	0.18	−0.066	0.16
Perseverative errors	−0.001	0.98	−0.017	0.71	−0.009	0.85
Nonperseverative errors	−0.105	0.023^†	−0.073	0.12	−0.103	0.026^†

FDR = false discovery rate; white matter A = genu of corpus callosum, right external capsule, right uncinate fasciculus, right inferior fronto-occipital fasciculus; white matter B = fornix, right optic tract; white matter C = left inferior fronto-occipital fasciculus, left straight gyrus white matter, left olfactory radiation.
↵* Significant at p_FDR < 0.05.
↵† Significant at p < 0.05 (uncorrected).