Table 1

Brain areas coupled to the accumbens shell

Brain areaVehicleOxycodoneMaravirocOxycodone/maraviroc
Accumbens core3.243.482.754.23
Ventral pallidum3.314.46−2.44*4.37
Endopiriform cortex3.413.022.873.04
Claustrum2.58NS2.63.44
Medial septum3.36NSNSNS
Lateral septum3.25NSNSNS
Ventral orbital cortex2.78NSNSNS
Dorsal medial striatum2.71NSNSNS
Ventral medial striatum2.76NSNSNS
Ventral lateral striatumNSNSNS3
Diagonal band of Broca2.62NSNSNS
Lateral orbital cortexNSNS3.08NS
Insular cortexNSNSNS3.19
Infralimbic cortex3.723.053.41NS
Prelimbic cortexNS2.62NSNS
Rostral piriform cortexNS3.112.66NS
Olfactory tuberclesNS2.66NSNS
Anterior olfactory nucleusNS2.53NSNS
Intercalated amygdalaNS2.92NSNS
Central amygdalaNS2.83NSNS
Extended amygdalaNS2.5NSNS
Bed nucleus of the stria terminalisNS2.86NSNS
Lateral preoptic areaNS3.91NSNS
Neural lobe pituitaryNS4.46NSNS
CA1 ventral hippocampusNS2.55NSNS
Cupola cerebellumNS3.96NSNS
Superior colliculusNSNSNS3.03
Flocculus cerebellumNSNS−3*NS
Locus coeruleusNSNS−3.3*NS
Periaqueductal gray regionNSNS−3.9*NS
Medial geniculate bodyNSNS−2.6*NS
  • NS = not significant.

  • * Decrease in connectivity.

  • Increase in connectivity.