Group | Region | Peak MNI coordinates, x, y, z | No. of voxels | SDM Z value | p value |
---|---|---|---|---|---|
Schizophrenia | Effect of illness duration | ||||
Altered activity in studies with longer illness duration | |||||
Right insula, BA 48 | 44, 8, −2 | 407 | 6.859 | < 0.001 | |
Left supplementary motor area | 0, 0, 50 | 128 | 6.345 | < 0.001 | |
Left supplementary motor area | 0, −2, 70 | 24 | 5.759 | < 0.001 | |
Right middle frontal gyrus, BA 6 | 46, −2, 56 | 22 | 5.934 | < 0.001 | |
Right caudate nucleus | 18, −2, 22 | 15 | 5.934 | < 0.001 | |
Left superior frontal gyrus, medial, BA 9 | −4, 48, 38 | 34 | −1.225 | < 0.001 | |
Effect of PANSS total score | |||||
Altered activity in studies with higher PANSS total score | |||||
None | |||||
Bipolar disorder | Effect of illness duration | ||||
Altered activity in studies with longer illness duration | |||||
Right middle frontal gyrus, BA 46 | 36, 56, 24 | 25 | −3.638 | < 0.001 | |
Effect of HAM-D score | |||||
Altered activity in studies with higher HAM-D score | |||||
Right thalamus | 10, −30, 4 | 82 | −2.417 | < 0.001 | |
Effect of YMRS score | |||||
Altered activity in studies with higher YMRS score | |||||
Left inferior frontal gyrus, orbital part, BA 47 | −34, 38, 10 | 372 | 2.705 | < 0.001 | |
Right inferior frontal gyrus, orbital part, BA 38 | 54, 24, 6 | 32 | 1.626 | < 0.001 | |
Left Heschl gyrus, BA 48 | −42, −22, 10 | 597 | −1.383 | < 0.001 |
BA = Brodmann area; HAM-D = Hamilton Depression Rating Scale; MNI = Montreal Neurological Institute; PANSS = Positive and Negative Syndrome Scale; SDM = seed-based d-mapping; YMRS = Young Mania Rating Scale.