Table 3

Regional homogeneity for schizophrenia and bipolar disorder — results of the meta-regression analyses

GroupRegionPeak MNI coordinates, x, y, zNo. of voxelsSDM
Z value
p value
SchizophreniaEffect of illness duration
 Altered activity in studies with longer illness duration
  Right insula, BA 4844, 8, −24076.859< 0.001
  Left supplementary motor area0, 0, 501286.345< 0.001
  Left supplementary motor area0, −2, 70245.759< 0.001
  Right middle frontal gyrus, BA 646, −2, 56225.934< 0.001
  Right caudate nucleus18, −2, 22155.934< 0.001
  Left superior frontal gyrus, medial, BA 9−4, 48, 3834−1.225< 0.001
 Effect of PANSS total score
 Altered activity in studies with higher PANSS total score
  None
Bipolar disorderEffect of illness duration
 Altered activity in studies with longer illness duration
  Right middle frontal gyrus, BA 4636, 56, 2425−3.638< 0.001
Effect of HAM-D score
 Altered activity in studies with higher HAM-D score
  Right thalamus10, −30, 482−2.417< 0.001
Effect of YMRS score
 Altered activity in studies with higher YMRS score
  Left inferior frontal gyrus, orbital part, BA 47−34, 38, 103722.705< 0.001
  Right inferior frontal gyrus, orbital part, BA 3854, 24, 6321.626< 0.001
  Left Heschl gyrus, BA 48−42, −22, 10597−1.383< 0.001
  • BA = Brodmann area; HAM-D = Hamilton Depression Rating Scale; MNI = Montreal Neurological Institute; PANSS = Positive and Negative Syndrome Scale; SDM = seed-based d-mapping; YMRS = Young Mania Rating Scale.