Table 1

Differences in regional homogeneity between patients with schizophrenia or bipolar disorder and healthy controls — results of the meta-analysis

Local maximumClusterEgger test (p value)Jackknife sensitivityHeterogeneity
RegionPeak MNI coordinates, x, y, zSDM
Z value		p valueNo. of voxelsBreakdown (no. of voxels)
Schizophrenia v. healthy controls
 Schizophrenia > healthy controls
  Right inferior frontal gyrus, triangular part, BA 4546, 20, 23.064< 0.0013156Right insula, BAs 47, 48 (704)
Right inferior frontal gyrus, triangular part, BAs 45, 47, 48 (401)
Right inferior frontal gyrus, orbital part, BAs 45, 46, 47 (320)
Right inferior frontal gyrus, opercular part, BAs 6, 38, 44, 45, 48 (309)
Right striatum (167)
Right lenticular nucleus, putamen, BAs 6, 38, 44, 45, 48 (309)
Right temporal pole, superior temporal gyrus, BAs 21, 38, 48 (201)
Right rolandic operculum, BAs 6, 48 (117)
Right middle frontal gyrus, orbital part, BAs 46, 47 (95)
Right superior temporal gyrus, BAs 21, 38, 48 (103)
Right Heschl gyrus, BA 48 (13)		0.1728/28N
  Right superior frontal gyrus, medial, BA 96, 44, 402.487< 0.0011628Left superior frontal gyrus, medial, BAs 8, 9, 32 (633)
Right superior frontal gyrus, BAs 8, 9, 10, 32 (332)
Right superior frontal gyrus, dorsolateral, BA 9 (95)
Right middle frontal gyrus, BAs 9, 46 (187)
Right median cingulate/paracingulate gyri, BAs 24, 32 (74)
Right anterior cingulate/paracingulate gyri, BA 32 (39)
Left anterior cingulate/paracingulate gyri, BAs 24, 32 (70)
Left supplementary motor area, BA 8 (22)
Right supplementary motor area, BA 8 (12)		0.1828/28N
  Left caudate nucleus−4, 10, 02.721< 0.0011580Left striatum (272)
Right caudate nucleus (83)
Left caudate nucleus, BA 25 (72)
Left olfactory cortex, BAs 25, 48 (63)
Left superior frontal gyrus, orbital part, BAs 11, 25 (35)
Left gyrus rectus, BA 11 (17)
Left lenticular nucleus, putamen, BA 25 (13)
Right striatum (12)		0.7628/28N
  Right supplementary motor area, BA 62, 4, 661.7380.003210.2428/28N
 Schizophrenia < healthy controls
  Left Heschl gyrus, BA 48−40, −18, 4−3.155< 0.0012450Left superior temporal gyrus, BAs 22, 41, 48 (718)
Left insula, BA 48 (409)
Left Heschl gyrus, BA 48 (171)
Left postcentral gyrus, BA 48 (80)
Left supramarginal gyrus, BA 48 (28)
Left middle temporal gyrus, BA 22 (22)		0.3828/28N
  Right middle temporal gyrus, BA 3748, −72, −2−3.325< 0.001940Right inferior occipital gyrus, BAs 19, 37 (259)
Right middle temporal gyrus, BAs 19, 37 (330)
Right inferior temporal gyrus, BAs 19, 37 (200)
Right inferior temporal gyrus, BA 19 (57)		0.3428/28N
  Right precentral gyrus, BA 450, −8, 36−2.064< 0.0011035Right postcentral gyrus, BAs 3, 4 43 (534)
Right precentral gyrus, BAs 4, 6 (405)		0.1528/28N
  Right cuneus cortex, BA 1912, −86, 30−2.294< 0.001727Right cuneus cortex, BAs 18, 19 (250)
Right superior occipital gyrus, BAs 18,19 (235)		0.7628/28N
  Left postcentral gyrus, BA 4−48, −18, 42−1.800< 0.001680Left postcentral gyrus, BAs 3, 4, 43 (517)
Left precentral gyrus, BA 4 (44)		0.7428/28N
  Left inferior occipital gyrus, BA 19−44, −74, −12−2.081< 0.001435Left inferior occipital gyrus, BAs 19, 37 (226)
Left middle occipital gyrus, BAs 19, 37 (129)
Left fusiform gyrus, BA 19 (37)		0.2728/28N
2, −32, 62−1.6390.002133Right paracentral lobule (58)
Left paracentral lobule (43)		0.1128/28N
Bipolar disorder v. healthy controls
 Bipolar disorder > healthy controls
  Left inferior frontal gyrus, orbital part, BA 47−32, 36, −82.917< 0.0011076Left inferior frontal gyrus, orbital part, BAs 11, 38, 46, 47 (568)
Left middle frontal gyrus, orbital part, BAs 11, 46, 47 (204)
Left middle frontal gyrus, orbital part, BA 46 (39)
Left inferior frontal gyrus, triangular part, BA 45 (30)		0.2321/21N
  Right superior frontal gyrus, dorsolateral, BA 822, 19, 521.663< 0.001602Right superior frontal gyrus, dorsolateral, BA 8 (138)
Right superior frontal gyrus, medial, BAs 8, 9 (145)
Right middle frontal gyrus, BA 8 (73)
Right supplementary motor area, BA 8 (36)
Left superior frontal gyrus, medial, BA 8 (16)
Right superior frontal gyrus, medial, BA 9 (13)		0.4021/21N
  Right gyrus rectus, BA 116, 28, −161.4140.001950.1319/21N
  Right striatum6, 12, −181.3890.001300.1019/21N
  Left inferior occipital gyrus, BA 19−44, −78, −61.2260.003280.01219/21N
 Bipolar disorder < healthy controls
  Left Heschl gyrus, BA 8−42, −22, 10−3.108< 0.0012257Left insula, BA 48 (468)
Left superior temporal gyrus, BA 48 (355)
Left Heschl gyrus, BA 48 (171)
Left lenticular nucleus, putamen, BA 48 (68)
Left postcentral gyrus, BA 48 (51)
Left superior temporal gyrus, BAs 22, 42, 42 (140)
Left striatum (16)		0.01021/21N
  Right inferior temporal gyrus, BA 1948, −72, −4−1.979< 0.001253Right inferior occipital gyrus, BA 19 (63)
Right middle temporal gyrus, BAs 19, 37 (64)
Right inferior temporal gyrus, BAs 19, 37 (75)
Right middle occipital gyrus, BA 37 (32)		0.0621/21N
  Right thalamus10, −28, 4−1.689< 0.0011250.0820/21N
  Left postcentral gyrus, BA 3−48, −24, 56−1.3990.003320.01219/21N

  • BA = Brodmann area; MNI = Montreal Neurological Institute; SDM = seed-based d-mapping.