Group differences: functional network connectivity*
| Independent component | Contrast | Brain region | Cluster, k | MNI coordinates, x, y, z | t statistic | Z score | pFDR (peak) |
|---|---|---|---|---|---|---|---|
| Independent component 3: DMN (whole brain) | Civilian-related PTSD > military- and law-enforcement-related PTSD | Precuneus | 43 | 14, −46, 54 | 5.67 | 5.38 | 0.009 |
| Independent component 3: DMN (region of interest) | Civilian-related PTSD > healthy controls | Periaqueductal grey | 39 | 0, −32, −8 | 4.95 | 4.75 | 0.028 |
| Cerebellar lobule VII | 49 | 10, −66, −40 | 4.44 | 4.29 | 0.046 | ||
| Military- and law-enforcement-related PTSD > healthy controls | Periaqueductal grey | 60 | 4, −30, −2 | 4.22 | 4.09 | 0.076† |
DMN = default mode network; FDR = false discovery rate; MNI = Montreal Neurological Institute; PTSD = posttraumatic stress disorder.
↵* Group-level functional network connectivity across the independent component correlated to the DMN is displayed for whole-brain and region-of-interest analyses; t contrasts were evaluated at a significance threshold of pFDR < 0.05, k > 10 (peak-corrected).
↵† Denotes a group difference approaching significance.