Clinical correlations: functional network connectivity
| Independent component | Group | Clinical score (direction) | Brain region | Cluster, k | MNI coordinates, x, y, z | t statistic | Z score | pFDR (peak) |
|---|---|---|---|---|---|---|---|---|
| Independent component 3: DMN (whole brain) | Military- and law-enforcement-related PTSD | State: shame (−) | Precentral gyrus | 24 | −36, −28, 40 | 8.29 | 5.18 | 0.049 |
| Independent component 3: DMN (region of interest) | Military- and law-enforcement-related PTSD | State: shame (+) | Cerebellar lobule IX | 24 | 2, −56, −24 | 8.10 | 5.12 | 0.006 |
| PTSD | Clinician-Administered PTSD Scale, total score (+) | Cerebellar lobule VII | 28 | 42, −60, −34 | 5.10 | 4.58 | 0.041 | |
| Clinician-Administered PTSD Scale, total score (−) | Brainstem | 19 | 14, −16, −18 | 4.96 | 4.48 | 0.049 |
DMN = default mode network; FDR = false discovery rate; MNI = Montreal Neurological Institute; PTSD = posttraumatic stress disorder.
Clinical correlations across group-level functional network connectivity are displayed; t contrasts were evaluated at a significance threshold of pFDR < 0.05, k > 10 (peak-corrected).