Table 2

Between-group differences in fractional anisotropy and white matter volume in regions of interest*

Tract of interestCluster size, voxelsMean value ± SDTFCE p valueCohen dMNI coordinates of peak voxel, x, y, z
PMDDControls
Fractional anisotropy, PMDD > controls
 Left dorsal cingulum bundle570.65 ± 0.060.61 ± 0.060.0310.71−9, −21, 33
 Right dorsal cingulum bundle260.59 ± 0.030.54 ± 0.030.0700.839, 9, 31
 Genu of the corpus callosum150.69 ± 0.040.64 ± 0.040.0950.87−14, 30, 16
 Right superior longitudinal fasciculus1150.60 ± 0.030.57 ± 0.030.0310.7539, −10, 29
 Left uncinate fasciculus300.58 ± 0.050.53 ± 0.040.024†0.69−35, −1, −13
 Right uncinate fasciculus120.62 ± 0.050.58 ± 0.050.0810.6734, 2, −12
White matter volume, PMDD > controls
 Right uncinate fasciculus1100.24 ± 0.050.22 ± 0.050.010†0.4036, 0, −14

  • MNI = Montreal Neurological Institute; PMDD = premenstrual dysphoric disorder; SD = standard deviation; TFCE = threshold-free cluster enhancement.

  • ↵* Threshold-free cluster enhancement voxel-wise comparisons of fractional anisotropy and white matter volume between individuals with PMDD and healthy controls in tracts of interest.

  • Mean raw values of fractional anisotropy and white matter volume were extracted from significant clusters and are presented for each group. Results are corrected for multiple comparisons using the family-wise error rate at p < 0.1 across voxels.

  • ↵† q < 0.1, corrected for false discovery rate across regions of interest.