Stimulant drug–induced behavioural sensitization in humans
| Study | No. of doses | d-Amphetamine regimen | Sensitization* |
|---|---|---|---|
| Johanson et al42 | 5 | 5.0 mg, p.o. | No — mood, no. of tablets chosen |
| Kelly et al43 | 6 | 10.0 mg, p.o. | No — speech rate, smoking, stimulant effects, liking |
| Kegeles et al52 | 2 | ~20 mg, i.v. (0.30 mg/kg) | No — euphoria, restless, anxiety |
| Wachtel et al53 | 2 | 20.0 mg, p.o. | No — subjective and psychomotor effects |
| Strakowski et al46 | 3 | ~20 mg, p.o. (0.25 mg/kg) | Yes — energy, eye-blink |
| Strakowski et al47 | 3 | ~20 mg, p.o. (0.25 mg/kg) | Yes — energy, euphoria |
| Strakowski et al48 | 2 | ~20 mg, p.o. (0.25 mg/kg) | Yes — energy, eye-blink, mood, speech rate |
| Boileau et al49 | 4–5 | ~20 mg, p.o. (0.30 mg/kg) | Yes — energy, eye-blink |
| O’Daly et al50 | 4 | ~20 mg, p.o. (0.30 mg/kg) | Yes — energy, euphoria |
| Childs et al51 | 2 | 20 mg, p.o. | No — stimulation, craving |
| Weidenauer et al44 | 4 | ~30 mg, p.o. (0.40 mg/kg) | Yes — lively, outgoing |
| Smart et al45 | 4 | ~20 mg, p.o. (0.30 mg/kg) | Yes — mind-racing, speech |
i.v. = intravenous; p.o. = oral.
↵* There is consistent evidence of amphetamine-induced behavioural sensitization in humans administered a minimum of 3 doses ≥ 0.25 mg/kg (6 of 6 studies).44–47,49,50