Statistical summary, Figure 1 and Figure 3*
| Figure | Outcome | Difference ± SD (controls − patients with MDD) | t (1 − α/2g, n − k) | p value | Power |
|---|---|---|---|---|---|
| 1 | rSUV, left sgACC | −0.165 ± 0.062 | −2.684 | 0.012 | 0.986 |
| 1 | rSUV, right sgACC | −0.077 ± 0.071 | −1.086 | 0.29 | 0.934 |
| 1 | rSUV, left insula | −0.091 ± 0.064 | −1.409 | 0.17 | 0.739 |
| 1 | rSUV, right insula | −0.100 ± 0.069 | −1.438 | 0.16 | 0.814 |
| 3 | Connectivity, left sgACC–left insula | 0.057 ± 0.078 | 0.725 | 0.47 | 0.407 |
| 3 | Connectivity, right sgACC–right insula | 0.136 ± 0.067 | 2.024 | 0.053 | 0.838 |
| 3 | Connectivity, left sgACC–right insula | 0.139 ± 0.070 | 1.973 | 0.059 | 0.792 |
| 3 | Connectivity, right sgACC–left insula | 0.092 ± 0.072 | 1.288 | 0.21 | 0.796 |
MDD = major depressive disorder; rSUV = relative standard uptake value; SD = standard deviation; sgACC = subgenual anterior cingulate cortex; TSPO = translocator protein.
↵* Group differences are presented after adjustment for age, sex and TSPO in a regression model. Bonferroni adjustments were applied to p values for simultaneous parameter estimates. α = 0.05, g indicates the number of parameters to be estimated jointly, k indicates the number of variables in the model and n − k represents degrees of freedom.