Table 3

Statistical summary, Figure 2 and Figure 5*

FigureOutcomePredictor (mean)Change ± SEtp valuePower
2AHAM-DrSUV, left insula (1.37760)−36.675 ± 14.670−2.5000.0390.880
2BHAM-DrSUV, right insula (1.30117)−30.151 ± 11.871−2.5400.0370.840
5ArSUV, left sgACCAxial diffusivity of the left cingulum (0.00091)3.282 ± 1.0423.1500.0230.683
5BrSUV, left sgACCFractional anisotropy of the left cingulum (0.30021)−0.154 ± 0.735−0.2100.840.419
5CrSUV, left sgACCMean diffusivity of the left cingulum (0.00068)2.110 ± 0.9822.1500.070.839
5DrSUV, left sgACCRadial diffusivity of the left cingulum (0.00057)1.238 ± 0.8091.5300.170.833
  • HAM-D = 17-item Hamilton Depression Rating Scale; rSUV = relative standard uptake value; SE = standard error; sgACC = subgenual anterior cingulate cortex.

  • * Represented are changes in microglial activity of the left sgACC associated with mean increase in diffusion tensor imaging scalars of the cingulum bundle, and changes in functional connectivity of the sgACC associated with mean increase in insular microglial activity.

  • p value associated with the absolute value of t.