Table 1

Participant characteristics

CharacteristicaPatients with first-episode schizophrenia
n = 63
Healthy controls
n = 48
Statisticp value
Male/female30/3328/20χ2 = 1.250.26
Age, yr27.5 ± 6.830.5 ± 7.8t = −2.180.31
Education, yr13.2 ± 3.313.8 ± 2.6t = −0.960.34
Age at onset, yr26.8 ± 7.5NANANA
Illness duration, mo11.6 ± 12.2NANANA
CTQ
 Emotional abuse subscore7.09 ± 2.316.00 ± 1.46z = −2.890.004
 Physical abuse subscore5.68 ± 1.585.40 ± 1.25z = −1.530.13
 Sexual abuse subscore6.05 ± 2.835.17 ± 0.37z = −2.310.020
 Emotional neglect subscore9.32 ± 4.027.67 ± 2.94z = −2.170.030
 Physical neglect subscore11.14 ± 2.2310.10 ± 1.36z = −2.420.016
 Total score39.29 ± 7.9134.33 ± 5.12z = −3.76< 0.001
MCCB
 Speed of processing subscore49.65 ± 11.1556.72 ± 7.55F = 44.81< 0.001
 Attention or vigilance subscore42.33 ± 8.7257.98 ± 7.01F = 87.14< 0.001
 Working memory subscore48.35 ± 9.8058.89 ± 5.45F = 36.170.002
 Verbal learning subscore49.65 ± 11.1556.73 ± 7.55F = 10.18 <0.001
 Visual learning subscore47.35 ± 9.5655.82 ± 6.04F = 10.18 <0.001
 Reason and problem-solving subscore49.10 ± 9.0257.05 ± 6.16F = 32.34< 0.001
 Social cognition subscore46.56 ± 8.5054.20 ± 10.26F = 12.580.001
 Composite score46.00 ± 8.3258.89 ± 5.80F = 78.95< 0.001
Right OFC H-shaped sulci volume, cm32.49 ± 0.262.52 ± 0.37F = 0.060.81
Left OFC H-shaped sulci volume, cm32.56 ± 0.312.69 ± 0.36F = 6.250.014
  • CTQ = Childhood Trauma Questionnaire; MCCB = MATRICS Consensus Cognitive Battery; NA = not applicable; OFC = orbitofrontal cortex.

  • * Adjusting for sex, age, education level and total intracranial volume as covariates in the general linear model. Values are mean ± standard deviation unless otherwise indicated.