Subcortical volume and group differences, general linear models
Structure | Subcortical volume, mm3* | F3,363 | p value | Post hoc comparisons | |||
---|---|---|---|---|---|---|---|
Schizophrenia n = 160 | Bipolar disorder n = 160 | MDD n = 160 | Healthy controls n = 160 | ||||
Thalamus | 7140.1 ± 760.7 | 7181.8 ± 867.0 | 7231.5 ± 808.4 | 7550.9 ± 750.1 | 6.0 | < 0.001† | Schizophrenia = bipolar disorder = MDD < healthy controls |
Hippocampus | 3881.9 ± 348.7 | 4017.4 ± 405.8 | 4054.1 ± 372.9 | 4183.9 ± 386.8 | 16.5 | < 0.001† | Schizophrenia < bipolar disorder < healthy controls; schizophrenia < MDD = healthy controls |
Amygdala | 1724.4 ± 207.7 | 1742.0 ± 221.0 | 1755.3 ± 213.9 | 1811.0 ± 221.3 | 3.6 | 0.014 | – |
Accumbens | 540.2 ± 103.4 | 560.6 ± 102.0 | 574.2 ± 101.9 | 593.8 ± 107.5 | 5.3 | 0.001† | Schizophrenia < MDD = healthy controls |
Putamen | 5186.6 ± 555.0 | 5076.7 ± 655.8 | 5068.3 ± 563.8 | 5279.1 ± 615.6 | 3.1 | 0.027 | – |
Caudate | 3722.9 ± 463.4 | 3599.6 ± 471.5 | 3695.9 ± 424.1 | 3763.0 ± 477.1 | 3.3 | 0.02 | – |
Pallidum | 1893.5 ± 238.9 | 1802.5 ± 241.4 | 1789.6 ± 215.8 | 1872.0 ± 222.5 | 10.9 | < 0.001† | Schizophrenia > bipolar disorder = MDD = healthy controls |
Lateral ventricle | 9387.7 ± 4844.2 | 9085.3 ± 4582.9 | 7635.5 ± 3992.4 | 7365.3 ± 3514.1 | 14.6 | < 0.001† | Schizophrenia = bipolar disorder > MDD = healthy controls |
Intracranial volume | 1 404 012.9 ± 183 873.2 | 1 419 487.3 ± 184 604.6 | 1 420 293.2 ± 152 378.9 | 1 460 416.2 ± 183 226.0 | – |