Regression models of the effects of the rostral cingulate cortex regions of interest on BASC-2 PRS T scores
| Group | Composite scales | Rostral cingulate cortex regions of interest* |
|---|---|---|
| Unexposed controls | Externalizing Problems (n = 47) | Right pregenual ACC (β = −0.317, p = 0.030) |
| Internalizing Problems (n = 47) | Right pregenual ACC (β = −0.369, p = 0.011, q = 0.09) | |
| Behavioural Symptoms Index (n = 47) | Right pregenual ACC (β = −0.409, p = 0.004, q = 0.06) Right total rostral cingulate cortex (β = −0.295, p = 0.044) | |
| Adaptive Skills (n = 47) | NS | |
| Individuals with prenatal alcohol exposure | Externalizing Problems (n = 28) | NS |
| Internalizing Problems (n = 29) | Right anterior MCC (β = 0.536, p = 0.003, q = 0.048) Right total rostral cingulate cortex (β = 0.474, p = 0.009, q = 0.075) | |
| Behavioural Symptoms Index (n = 29) | Right anterior MCC (β = 0.429, p = 0.020) Left anterior MCC (β = 0.385, p = 0.038) | |
| Adaptive Skills (n = 29) | Right anterior MCC (β = −0.374, p = 0.046) Left anterior MCC (β = −0.369, p = 0.049) |
ACC = anterior cingulate cortex; BASC-2-PRS = Behaviour Assessment System for Children, 2nd edition, Parent Rating Scale; FDR = false discovery rate; MCC = midcingulate cortex; NS = not significant.
↵* Benjamini–Hochberg FDR-corrected p values are shown as q values. For Benjamini–Hochberg FDR correction, we assumed 8 tests for the associations between the BASC-2 PRS and total rostral cingulate cortex volume and 16 tests for the associations between the BASC-2 PRS and subregion volumes.