Table 3

Interaction analysis: condition (“reward” or “loss”) × anhedonia (Social and Physical Anhedonia Scale)*

Cluster Region, hemisphereCluster size, kMNI coordinates at peak, x, y, zTFCEF1,357pFWE
Cluster 1113132, 26, −638470.0024.75< 0.001
 Putamen, right
 Insula, right
 Superior, middle and inferior fronto-orbital cortex, right
Cluster 2897−30, 22, −431536.9526.62< 0.001
 Pallidum, left
 Putamen, left
 Insula, left
 Triangular part of inferior frontal cortex, left
 Superior temporal pole, left
 Inferior fronto-orbital cortex, left
Cluster 36696, 4, 3821788.7220.620.001
 Anterior and middle cingulate cortex, bilateral
 Supplementary motor area, left
 Superior medial frontal cortex, left
Cluster 42654, −42, 268999.5115.360.011
 Middle and posterior cingulate cortex, bilateral
 Precuneus, right
Cluster 514614, −8, 209379.1417.370.010
 Caudate nucleus, right
Cluster 663−12, −38, 404133.9211.520.037
 Middle cingulate cortex, bilateral
Cluster 732−34, 50, −1430624.3630.7< 0.001
 Middle and inferior fronto-orbital cortex, left
  • FWE = family-wise error; MNI = Montreal Neurological Institute; TFCE = threshold-free cluster enhancement.

  • * The region of interest comprised the orbitofrontal cortex, insula, cingulate cortex, caudate nucleus, putamen and nucleus accumbens. Analyses were performed using TFCE with a voxel threshold of pFWE < 0.05 and a minimum cluster volume threshold of k > 30.