Main effect of anhedonia (Social and Physical Anhedonia Scale)*
| Cluster Region, hemisphere | Cluster size, k | MNI coordinates at peak, x, y, z | TFCE | F1,357 | pFWE |
|---|---|---|---|---|---|
| Cluster 1 | 2234 | −30, 22, −4 | 6147.35 | 15.49 | < 0.001 |
| Insula, left | |||||
| Putamen, left | |||||
| Caudate nucleus, bilateral | |||||
| Pallidum, left | |||||
| Ventral striatum, bilateral | |||||
| Anterior, lateral and posterior orbitofrontal cortex, left | |||||
| Inferior fronto-orbital cortex, left | |||||
| Anterior cingulate cortex, left | |||||
| Cluster 2 | 2202 | 32, 26, −6 | 7376.92 | 14.38 | < 0.001 |
| Insula, right | |||||
| Putamen, right | |||||
| Pallidum, right | |||||
| Caudate nucleus, right | |||||
| Ventral striatum, right | |||||
| Anterior, medial and posterior orbitofrontal cortex, right | |||||
| Inferior fronto-orbital cortex, right | |||||
| Cluster 3 | 2066 | 6, 4, 38 | 4277.24 | 12.07 | < 0.001 |
| Anterior and middle cingulate cortex, bilateral | |||||
| Posterior cingulate cortex, right | |||||
| Cluster 4 | 54 | −34, 50, −14 | 6108.14 | 17.94 | < 0.001 |
| Anterior and lateral orbitofrontal cortex, left | |||||
| Inferior fronto-orbital cortex, left | |||||
| Cluster 5 | 41 | 16, 22, 6 | 381.07 | 5.38 | 0.027 |
| Caudate nucleus, right |
FWE = family-wise error; MNI = Montreal Neurological Institute; TFCE = threshold-free cluster enhancement.
↵* The region of interest comprised the orbitofrontal cortex, insula, cingulate cortex, caudate nucleus, putamen and nucleus accumbens. Analyses were performed using TFCE with a voxel threshold of pFWE < 0.05 and a minimum cluster volume threshold of k > 30.