Table 2

Main effect of anhedonia (Social and Physical Anhedonia Scale)*

Cluster Region, hemisphereCluster size, kMNI coordinates at peak, x, y, zTFCEF1,357pFWE
Cluster 12234−30, 22, −46147.3515.49< 0.001
 Insula, left
 Putamen, left
 Caudate nucleus, bilateral
 Pallidum, left
 Ventral striatum, bilateral
 Anterior, lateral and posterior orbitofrontal cortex, left
 Inferior fronto-orbital cortex, left
 Anterior cingulate cortex, left
Cluster 2220232, 26, −67376.9214.38< 0.001
 Insula, right
 Putamen, right
 Pallidum, right
 Caudate nucleus, right
 Ventral striatum, right
 Anterior, medial and posterior orbitofrontal cortex, right
 Inferior fronto-orbital cortex, right
Cluster 320666, 4, 384277.2412.07< 0.001
 Anterior and middle cingulate cortex, bilateral
 Posterior cingulate cortex, right
Cluster 454−34, 50, −146108.1417.94< 0.001
 Anterior and lateral orbitofrontal cortex, left
 Inferior fronto-orbital cortex, left
Cluster 54116, 22, 6381.075.380.027
 Caudate nucleus, right
  • FWE = family-wise error; MNI = Montreal Neurological Institute; TFCE = threshold-free cluster enhancement.

  • * The region of interest comprised the orbitofrontal cortex, insula, cingulate cortex, caudate nucleus, putamen and nucleus accumbens. Analyses were performed using TFCE with a voxel threshold of pFWE < 0.05 and a minimum cluster volume threshold of k > 30.