Table 5

Indirect volume comparisons between patients with schizophrenia and patients with MDD

Region of interestMean difference (95% CI), mm3p value*
Left whole hippocampus−52.842 (−182.380 to 76.696)0.67
 Left CA1−8.347 (−29.661 to 12.966)0.67
 Left CA32.936 (−4.428 to 10.300)0.67
 Left CA41.262 (−6.139 to 8.663)0.77
 Left granule cell layer of the dentate gyrus−1.719 (−10.501 to 7.063)0.77
 Left subiculum−2.665 (−14.354 to 9.025)0.77
 Left presubiculum−7.914 (−17.431 to 1.602)0.34
 Left parasubiculum†−3.506 (−5.755 to −1.256)0.03
 Left molecular layer−14.488 (−30.416 to 1.440)0.32
 Left hippocampal tail−20.513 (−47.148 to 6.122)0.34
 Left fimbria2.633 (−4.420 to 9.687)0.67
 Left hippocampal fissure0.941 (−5.357 to 7.239)0.77
 Left HATA−2.672 (−4.761 to −0.584)0.08
Right whole hippocampus−69.772 (−184.654 to 45.111)0.43
 Right CA1−7.067 (−25.997 to 11.863)0.75
 Right CA31.990 (−5.337 to 9.317)0.77
 Right CA42.404 (−5.432 to 10.240)0.77
 Right granule cell layer of the dentate gyrus−0.362 (−8.383 to 7.659)1.00
 Right subiculum−0.426 (−12.542 to 11.691)1.00
 Right presubiculum−9.261 (−19.302 to 0.780)0.25
 Right parasubiculum†−4.016 (−6.935 to −1.097)0.046
 Right molecular layer−15.580 (−33.907 to 2.748)0.25
 Right hippocampal tail−19.950 (−42.993 to 3.094)0.25
 Right fimbria0.011 (−5.489 to 5.510)1.00
 Right hippocampal fissure4.849 (−1.513 to 11.211)0.29
 Right HATA†−5.140 (−6.940 to −3.340)< 0.001

  • CA = cornu ammonis; CI = confidence interval; HATA = hippocampus–amygdala transition area; MDD = major depressive disorder.

  • ↵* Adjusted.

  • ↵† Statistically significant difference.