Direct volume comparisons between patients with schizophrenia and healthy controls
Region of interest | Mean difference (95% CI), mm3 | p value* | I2, % | No. of studies | No. of patients with schizophrenia | No. of healthy controls |
---|---|---|---|---|---|---|
Left whole hippocampus† | −127.840 (−209.381 to −46.298) | 0.005 | 49 | 6 | 700 | 649 |
Left CA1† | −21.721 (−36.328 to −7.113) | 0.006 | 0 | 7 | 779 | 731 |
Left CA3 | −4.555 (−9.580 to 0.471) | 0.08 | 42 | 7 | 779 | 731 |
Left CA4† | −6.875 (−11.728 to −2.021) | 0.008 | 45 | 7 | 779 | 731 |
Left granule cell layer of the dentate gyrus† | −8.430 (−14.089 to −2.771) | 0.006 | 44 | 7 | 779 | 731 |
Left subiculum† | −10.245 (−18.124 to −2.366) | 0.01 | 36 | 7 | 779 | 731 |
Left presubiculum† | −7.667 (−14.219 to −1.116) | 0.03 | 2 | 6 | 578 | 606 |
Left parasubiculum† | −3.041 (−4.531 to −1.551) | < 0.001 | 0 | 5 | 539 | 576 |
Left molecular layer† | −17.412 (−27.110 to −7.714) | 0.002 | 0 | 7 | 779 | 731 |
Left hippocampal tail† | −24.456 (−40.346 to −8.566) | 0.006 | 74 | 7 | 779 | 731 |
Left fimbria | −2.008 (−5.401 to 1.385) | 0.25 | 20 | 5 | 539 | 576 |
Left hippocampal fissure† | 4.941 (1.953 to 7.930) | 0.004 | 0 | 5 | 539 | 576 |
Left HATA† | −2.044 (−3.156 to −0.932) | 0.002 | 23 | 5 | 539 | 576 |
Right whole hippocampus† | −108.803 (−182.105 to −35.500) | 0.01 | 35 | 6 | 700 | 649 |
Right CA1† | −16.337 (−29.533 to −3.140) | 0.02 | 32 | 7 | 779 | 731 |
Right CA3 | −2.776 (−7.850 to 2.299) | 0.28 | 30 | 7 | 779 | 731 |
Right CA4 | −4.929 (−10.152 to 0.293) | 0.07 | 47 | 7 | 779 | 731 |
Right granule cell layer of the dentate gyrus† | −6.657 (−11.976 to −1.338) | 0.02 | 38 | 7 | 779 | 731 |
Right subiculum† | −8.764 (−17.057 to −0.472) | 0.049 | 8 | 7 | 779 | 731 |
Right presubiculum | −7.051 (−14.077 to −0.024) | 0.06 | 0 | 6 | 578 | 606 |
Right parasubiculum† | −2.899 (−4.797 to −1.001) | 0.01 | 27 | 5 | 539 | 576 |
Right molecular layer† | −13.845 (−25.233 to −2.457) | 0.02 | 23 | 7 | 779 | 731 |
Right hippocampal tail† | −17.221 (−31.208 to −3.234) | 0.02 | 18 | 7 | 779 | 731 |
Right fimbria† | −4.201 (−6.586 to −1.816) | 0.003 | 0 | 5 | 539 | 576 |
Right hippocampal fissure† | 9.849 (6.728 to 12.970) | < 0.001 | 0 | 5 | 539 | 576 |
Right HATA† | −2.727 (−3.787 to −1.667) | < 0.001 | 0 | 5 | 539 | 576 |