Table 3

Direct volume comparisons between patients with schizophrenia and healthy controls

Region of interestMean difference (95% CI), mm3p value*I2, %No. of studiesNo. of patients with schizophreniaNo. of healthy controls
Left whole hippocampus†−127.840 (−209.381 to −46.298)0.005496700649
 Left CA1†−21.721 (−36.328 to −7.113)0.00607779731
 Left CA3−4.555 (−9.580 to 0.471)0.08427779731
 Left CA4†−6.875 (−11.728 to −2.021)0.008457779731
 Left granule cell layer of the dentate gyrus†−8.430 (−14.089 to −2.771)0.006447779731
 Left subiculum†−10.245 (−18.124 to −2.366)0.01367779731
 Left presubiculum†−7.667 (−14.219 to −1.116)0.0326578606
 Left parasubiculum†−3.041 (−4.531 to −1.551)< 0.00105539576
 Left molecular layer†−17.412 (−27.110 to −7.714)0.00207779731
 Left hippocampal tail†−24.456 (−40.346 to −8.566)0.006747779731
 Left fimbria−2.008 (−5.401 to 1.385)0.25205539576
 Left hippocampal fissure†4.941 (1.953 to 7.930)0.00405539576
 Left HATA†−2.044 (−3.156 to −0.932)0.002235539576
Right whole hippocampus†−108.803 (−182.105 to −35.500)0.01356700649
 Right CA1†−16.337 (−29.533 to −3.140)0.02327779731
 Right CA3−2.776 (−7.850 to 2.299)0.28307779731
 Right CA4−4.929 (−10.152 to 0.293)0.07477779731
 Right granule cell layer of the dentate gyrus†−6.657 (−11.976 to −1.338)0.02387779731
 Right subiculum†−8.764 (−17.057 to −0.472)0.04987779731
 Right presubiculum−7.051 (−14.077 to −0.024)0.0606578606
 Right parasubiculum†−2.899 (−4.797 to −1.001)0.01275539576
 Right molecular layer†−13.845 (−25.233 to −2.457)0.02237779731
 Right hippocampal tail†−17.221 (−31.208 to −3.234)0.02187779731
 Right fimbria†−4.201 (−6.586 to −1.816)0.00305539576
 Right hippocampal fissure†9.849 (6.728 to 12.970)< 0.00105539576
 Right HATA†−2.727 (−3.787 to −1.667)< 0.00105539576

  • CA = cornu ammonis; CI = confidence interval; HATA = hippocampus–amygdala transition area.

  • ↵* Adjusted.

  • ↵† Statistically significant difference.