Altered thalamocortical functional connectivity in youth with ADHD based on anatomically defined thalamic seeds*
| Functional connectivity | Peak coordinates, x, y, z | Statistics | ||
|---|---|---|---|---|
| KE, voxels | Z | p value | ||
| ADHD < controls | ||||
| Mediodorsal thalamus to visual network (small-volume correction) | −12, −64, 18 | 22 | 3.87 | 0.018 |
| Mediodorsal thalamus to visual network (small-volume correction) | 8, −56, 6 | 16 | 3.55 | 0.040 |
| Mediodorsal thalamus to default mode network (small-volume correction) | −12, −56, 10 | 21 | 4.03 | 0.031 |
| Mediodorsal thalamic seed (whole-brain analysis) | −12, −56, 10 | 50 | 4.03 | 0.008 |
| Positive correlation with IA score in ADHD | ||||
| Mediodorsal thalamus to dorsal attention network (small-volume correction) | −28, −72, 30 | 15 | 4.11 | 0.034 |
| Positive correlation with HI score in ADHD | ||||
| Lateral geniculate thalamus to frontoparietal network (small-volume correction) | 20, 60, −2 | 19 | 4.61 | 0.021 |
| Interaction effect (connectivity × diagnosis) on IA score | ||||
| Mediodorsal thalamus to dorsal attention network (small-volume correction) | 32, −64, 30 | 17 | 4.53 | 0.027 |
ADHD = attention-deficit/hyperactivity disorder; FWE = family-wise error; HI = hyperactivity/impulsivity; IA = inattention; KE = cluster extent.
↵* Positive and negative x coordinates indicate right and left hemispheres, respectively. Results are displayed with a cluster-defining threshold of pFWE < 0.05.