Table 2

Regions with altered nodal centralities

Brain region^*	p value

	Nodal degree	Nodal efficiency	Nodal betweenness
Low-risk v. high-risk v. healthy controls
Left parahippocampal gyrus (DMN)	0.0015^*	0.0037	0.0166
Right gyrus rectus (DMN)	0.0035^*	0.0012^*	0.2399
Right inferior frontal gyrus, triangular part (CEN)	0.0016^*	0.0003^*	0.0210
Right superior parietal gyrus (CEN)	0.0033^*	0.0014^*	0.0209
Right inferior frontal gyrus, opercular part (SN)	0.0074	0.0038	0.0011^*
Right rolandic operculum	0.0101	0.0020^*	0.2190
Right inferior occipital gyrus	0.0118	0.0035^*	0.4445
Low-risk v. healthy controls
Left parahippocampal gyrus (DMN)	0.0003^*↓	0.0010^*↓	0.0013^*↓
Right gyrus rectus (DMN)	0.0194^*↑	0.0175^*↑	0.0439
Right inferior frontal gyrus, triangular part (CEN)	0.0148^*↑	0.0174^*↑	0.0523↑
Right superior parietal gyrus (CEN)	0.0061^*↑	0.0089^*↑	0.0118^*↑
Right rolandic operculum	0.0019^*↑	0.0013^*↑	0.0430
High-risk v. healthy controls
Left parahippocampal gyrus (DMN)	0.0076^*↓	0.0418^*↓	0.0260^*↓
Right gyrus rectus (DMN)	0.0001^*↑	0.0001^*↑	0.1711
Right inferior frontal gyrus, triangular part (CEN)	0.0004^*↑	0.0002^*↑	0.0018^*↑
Right superior parietal gyrus (CEN)	0.0014^*↑	0.0008^*↑	0.0120^*↑
Right inferior frontal gyrus, opercular part (SN)	0.0015^*↑	0.0006^*↑	0.0002^*↑
Right rolandic operculum	0.0055^*↑	0.0009^*↑	0.1115
Right inferior occipital gyrus	0.0045^*↓	0.0008^*↓	0.4641
High-risk v. low-risk
Right inferior frontal gyrus, opercular part (SN)	0.0016^*↑	0.0008^*↑	0.0003^*↑
Right inferior occipital gyrus	0.0075^*↓	0.0028^*↓	0.1444↓

DMN = default mode network; CEN = central executive network; FDR = false discovery rate; SN = salience network.
↵* Brain regions were considered abnormal if they exhibited significant differences across groups or between 2 groups (p < 0.05, FDR corrected) in at least 1 node centrality parameter (marked by asterisk). All p values were obtained using a permutation test. The upward arrow signifies an increase in the measured value of the first group compared to the latter, whereas the downward arrow signifies a decrease in the measured value of the first group compared to the latter.