Summary of change over 3 years of treatment with metformin
| Characteristic | Pre-metformin (September 2019) | Post-metformin (July 2022) | Change over ~3 years |
|---|---|---|---|
| Metabolic profile | |||
| Weight | 95.6 kg | 49.2 kg | −46.4 kg |
| Waist circumference | 108 cm | 65 cm | −43 cm |
| BMI | 42.5 kg/m2 | 21.9 kg/m2 | −20.6 kg/m2 |
| Fasting glucose | 6.4 mmol/L* | 5.6 mmol/L | −0.8 mmol/L |
| Fasting insulin | 297 pmol/L* | 61 pmol/L | −236 pmol/L |
| HOMA-IR | 14.1 | 2.5 | −11.6 |
| Triglycerides | 2.35 mmol/L* | 1.26 mmol/L | −1.09 mmol/L |
| Total cholesterol | 5.87 mmol/L* | 5.04 mmol/L | −0.83 mmol/L |
| Low-density lipoprotein cholesterol | 2.93 mmol/L* | 2.28 mmol/L | −0.65 mmol/L |
| High-density lipoprotein cholesterol | 1.87 mmol/L* | 2.19 mmol/L | 0.32 mmol/L |
| Cognitive measures | |||
| Category Fluency Test | 17 points | 22 points | 5 points |
| Digit Symbol Substitution Test | 51 points | 58 points | 7 points |
| Trail Making Test A | 25.64 s, 1 mistake | 18.87 s, 0 mistakes | −6.77 s |
| Trail Making Test B | 45.04 s, 0 mistakes | 36.52 s, 1 mistake | −8.52 s |
| Psychopathology measures | |||
| Brief Psychiatric Rating Scale – total score | 31 | 28 | 5 |
| Clinical Global Impressions Scale | 5 | 4 | 1 |
BMI = body mass index; HOMA-IR = Homeostatic Model Assessment for Insulin Resistance.
↵* Bloodwork reported from about 3 months into metformin treatment (December 2019).