Regular ArticleAbnormal Functional Connectivity in Posttraumatic Stress Disorder
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2009, Clinical NeurophysiologyCitation Excerpt :WM updating abnormalities in PTSD have also been found to be associated with symptoms of intrusions and avoidance, providing preliminary evidence that these symptoms are related to the withdrawal of WM resources from stimulus information processing (Weber et al., 2005). These findings, our previous ERP studies (McFarlane et al., 1993; Galletly et al., 2001) and functional neuroimaging studies of PTSD (Shaw et al., 2002, 2009; Clark et al., 2003; Moores et al., 2008) have all identified abnormalities in frontal and parietal systems associated with WM impairments in PTSD. Research has demonstrated that chronic stress selectively disrupts WM operations (Mizoguchi et al., 2000) possibly via prefrontal dopaminergic systems (Arnsten, 1998; Arnsten and Goldman-Rakic, 1998).